解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Interleukin-17A (IL-17A) contributes to the pathogenesis of arthritis. Data from experimental arthritis indicate IL-17 receptor signaling as a critical pathway in turning an acute synovitis into a chronic destructive arthritis. The identification of six IL-17 family members (IL-17A-F) may extend the role of this novel...
journal_title:Cytokine
pub_type: 杂志文章,评审
doi:10.1016/j.cyto.2007.09.014
更新日期:2008-02-01 00:00:00
abstract:BACKGROUND:Resistin is a novel cysteine-rich protein that plays a role in the development of insulin resistance and atherosclerosis in rodents, while its role in humans is unclear. C-reactive protein (CRP) is an important risk predictor for coronary heart disease, and it can also modify the expression of genes involved...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2007.09.011
更新日期:2007-12-01 00:00:00
abstract::The present study demonstrates that liposomes coated with synthesized neoglycolipids constructed from mannotriose and dipalmitoylphosphatidylethanolamine (Man3-DPPE) activate peritoneal macrophages (PEMs) to up-regulate expression of co-stimulatory molecules and preferentially secrete IL-12. Injection of Man3-DPPE-coa...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2007.10.005
更新日期:2007-12-01 00:00:00
abstract:OBJECTIVE:We investigated the expression pattern and the role of inflammatory cytokines and their receptors in the placentas of pregnancy with HELLP syndrome. STUDY DESIGN:Placentas were collected after cesarean section, 10 from normal pregnancy and 10 from HELLP. The array was performed with GEArray Q Series Human In...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2007.08.010
更新日期:2007-11-01 00:00:00
abstract::LIGHT (lymphotoxin-like inducible protein that competes with glycoprotein D for binding herpesvirus entry mediator on T cells) is a recently identified of the tumor necrosis factor alpha (TNF-alpha) ligand superfamily. We wanted to establish whether the presence of chronic viral hepatitis could be implicated in enhanc...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2007.07.189
更新日期:2007-09-01 00:00:00
abstract::We previously isolated quercetin 3-O-beta-(2''-galloyl)-glucopyranoside (QG-32) from Persicaria lapathifolia (Polygonacease) as an inhibitor of superoxide production. In the present study, QG-32 was found to inhibit interleukin (IL)-6 production in endotoxin lipopolysaccharide (LPS)-stimulated macrophages RAW 264.7. T...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2007.08.002
更新日期:2007-09-01 00:00:00
abstract::The pleiotropic cytokine, interleukin-6 (IL-6), has emerged in recent years as a key regulator of the transition from innate to adaptive immunity through its ability to modulate leukocyte recruitment at inflammatory sites. This review highlights a newly identified role for IL-6 trans-signaling, initiated by an agonist...
journal_title:Cytokine
pub_type: 杂志文章,评审
doi:10.1016/j.cyto.2007.07.184
更新日期:2007-07-01 00:00:00
abstract::Inflammatory processes are implicated in gastric cancer development. In contrast, the role of inflammation and proinflammatory cytokines in established cancer remains to be clarified. We investigated the contribution of IL-17A versus IL-17F-mediated intracellular signalling pathways in human gastric adenocarcinoma AGS...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2007.06.002
更新日期:2007-06-01 00:00:00
abstract::We have investigated phosphatidylinositol 3-kinase (PI3K)-dependent survival signalling pathways using several cytokines in three different hemopoietic cell lines, MC/9, FDC-P1, and TF-1. Cytokines caused PI3K- and PKB-dependent phosphorylation of FOXO3a (previously known as FKHRL1) at three distinct sites. Following ...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2007.05.004
更新日期:2007-05-01 00:00:00
abstract::Inflammatory bowel diseases are characterized by dysregulated immune response to the normal microflora and structural and functional changes of the enteric nervous system which occur in inflamed as well as non-inflamed areas of the bowel. This study describes the changes in the expression of nerve growth factor (NGF) ...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2007.04.005
更新日期:2007-03-01 00:00:00
abstract::Transforming Growth Factor-beta (TGFbeta) is known to be a negative regulator of G1 cyclin/cdk activity. It is not clear whether TGFbeta has any effect on G2 checkpoint kinases. We have found that TGFbeta downregulated the expression of several G2 checkpoint kinases including cdc2, cyclin B1, and cdc25c without causin...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2007.03.009
更新日期:2007-02-01 00:00:00
abstract::We had earlier shown that human foetal epithelial cells (WISH), growth-inhibited by interferon gamma (IFNgamma), were reversibly detained at a point prior to DNA synthesis. In the present study, we determined the window of action of IFNgamma in the G1 phase duration and the exact point of detention of WISH cells in ce...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2007.02.013
更新日期:2007-02-01 00:00:00
abstract::Chronic elevation of circulating Interleukin-6 (IL-6) is observed in elderly individuals as well as in several illnesses, including chronic kidney diseases. A number of cells and tissues possess the ability to metabolize significant amounts of IL-6 in vitro. However, information on signals and mechanisms by which IL-6...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2007.02.015
更新日期:2007-01-01 00:00:00
abstract::In the present study, we investigated the effect of CdCl2 on the inflammatory cytokines in human intestinal Caco-2 cells. The secretion of IL-8 from Caco-2 cells was significantly increased in a dose- and time-dependent manner, whereas the secretion of such other inflammatory cytokines as TNF-alpha and IFN-gamma was n...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2007.02.011
更新日期:2007-01-01 00:00:00
abstract::The aim of this study is to investigate the relationship between chemokines and the inflammation in Familial Mediterranean Fever (FMF). Forty-nine patients with FMF (41 in remission and 8 in acute attack period) and 20 healthy controls were included in the study. Serum levels of macrophage inflammatory protein-1alpha ...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2006.12.005
更新日期:2007-01-01 00:00:00
abstract::Leptin-deficient ob/ob mice exhibit several metabolic and immune abnormalities, including thymus atrophy and markedly reduced inflammatory responses. We evaluated whether transplantation of wild-type (WT) white adipose tissue (WAT) into ob/ob mice could mimic the effect of recombinant leptin administration in normaliz...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2007.02.001
更新日期:2006-12-01 00:00:00
abstract::There are limited and conflicting studies investigating the role of the angiopoietin family in human thyroid cancer development and progression. We have investigated cytokines angiopoietin-1, -2 and their receptor (Tie-2), known to be involved in angiogenesis, in the serum of 52 thyroid cancer patients (21 cases of pa...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2007.02.008
更新日期:2006-12-01 00:00:00
abstract::Transforming growth factor-beta1 (TGFbeta1) induces plasminogen activator inhibitor-1 (PAI-1) as a major target protein. PAI-1 is associated with fibrosis, thrombosis, and metabolic disorders. TGFbeta1 induces PAI-1 via phosphorylation and nuclear translocation of Smads. Oltipraz inhibits TGFbeta1 expression and also ...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2006.10.001
更新日期:2006-09-01 00:00:00
abstract:BACKGROUND:Why severity varies in blastomycosis outbreaks remains unresolved. In experimental pulmonary blastomycosis, susceptibility varied in mouse strains. In susceptible BALB/c the response is Th-2, in immunized, resistance is associated with Th-1. Can susceptibility be redirected by IL-12? Methods, results: BALB/c...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2006.08.004
更新日期:2006-09-01 00:00:00
abstract::Nerve growth factor (NGF), which is a neurotrophic factor, is involved in autoimmune and inflammatory processes. Serum NGF levels were investigated in 131 patients with autoimmune (95 with Graves' disease, of whom 57 had ophthalmopathy, 19 with Hashimoto's thyroiditis) and nonimmune thyroid diseases (17 with toxic nod...
journal_title:Cytokine
pub_type: 杂志文章,评审
doi:10.1016/j.cyto.2006.08.002
更新日期:2006-08-01 00:00:00
abstract:BACKGROUND:Systemic Lupus Erythematosus (SLE) is an autoimmune disease characterized by a wide variety of autoantibodies, some of which are pathogenic. In recent years it has become more evident that the polyclonal B cell activation in SLE is T-cell dependent. The stimulation of the autoantibody producing B cells is li...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2006.07.023
更新日期:2006-08-01 00:00:00
abstract::The purpose of the study was to reassess the utility of transforming growth factor-beta-1 (TGF-beta1) together with dosimetric and tumor parameters as a predictor for radiation pneumonitis (RP). Of the 121 patients studied, 32 (26.4%) developed grade > or =1 RP, and 27 (22.3%) developed grade > or =2 RP. For the endpo...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2006.07.021
更新日期:2006-08-01 00:00:00
abstract::The aim of this study was to identify key cytokine polymorphisms associated with disease susceptibility, clinical phenotype, and outcome in patients with chronic anterior uveitis (CAU) as compared to those with recurrent self-limiting anterior uveitis (RAU). One hundred fifty seven British Caucasian patients with ante...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2006.08.003
更新日期:2006-08-01 00:00:00
abstract::Interleukin-21 (IL-21) is an important immune cytokine that was well characterized in human and mammals, but little is known in fish. In present study, an IL-21 homologue was cloned and well characterized from Tetraodon nigroviridis. The full-length Tetraodon IL-21 cDNA was 849bp in size, containing an open reading fr...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2006.07.010
更新日期:2006-08-01 00:00:00
abstract:OBJECTIVES:Vascular endothelial growth factor (VEGF) is a potent stimulus of angiogenesis that has an important role in many human malignancies including prostate carcinoma (PCa). We evaluated the role of the functional VEGF polymorphisms as genetic markers for PCa susceptibility and prognosis. METHODS:The study inclu...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2006.07.003
更新日期:2006-07-01 00:00:00
abstract::We evaluated the changes of metallothionein induction and cellular zinc distribution in HepG2 cells by interferonbeta treatment. Immunohistochemical staining of metallothionein was observed in the cytoplasm and nuclei of hepatocytes; which was observed predominantly in the cells treated with interferon and zinc compar...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2006.06.008
更新日期:2006-06-01 00:00:00
abstract::Asthma and type I diabetes are major causes of chronic illness in childhood which, according to the current paradigm, have mutually antagonistic immunopathologies. Nonetheless, the disorders appear to preferably coexist both on population and individual levels. To assess whether children with asthma and type I diabete...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2006.04.015
更新日期:2006-05-01 00:00:00
abstract::Since liver regeneration after partial hepatectomy (PHx) is known to improve by pretreatment with recombinant human G-CSF (rhG-CSF), we investigated the mechanism by evaluating the distribution and activity of sinusoidal NK cells. F344 rats were treated with rhG-CSF (250 microg/kg/day) for 5 days before PHx. Pretreatm...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2006.04.001
更新日期:2006-04-01 00:00:00
abstract::Data exist linking elevated epithelial neutrophil activating peptide (ENA-78) concentrations with myriad inflammatory conditions. ENA-78 is encoded by the CXCL5 gene which has recently been shown to be polymorphic in nature (rs352046 and rs425535). No functional data on these polymorphisms exist. We investigated wheth...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2006.02.008
更新日期:2006-03-07 00:00:00
abstract::Interleukin (IL)-4, IL-10, and IL-13 are T-helper2 cell derived cytokines, which are known to suppress pro-inflammatory cytokine production. The biologically related IL-4 and IL-13 have an impact on the development of atopic inflammation, whereas IL-10 is mostly supposed to be involved in fibrotic disorders or inflamm...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2006.01.007
更新日期:2006-02-21 00:00:00
abstract::Granulocyte colony-stimulating factor (G-CSF) is the major cytokine involved in the control of neutrophil development. G-CSF activates the special receptor, the G-CSF receptor (GCSF-R), which subsequently triggers multiple signaling events. To obtain more interactive molecules with GCSF-R and to further understand the...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2006.01.008
更新日期:2006-02-21 00:00:00
abstract::Non-Hodgkin's lymphomas (NHL) constitute a heterogenous group of mainly B-cell lymphoproliferative diseases with different patterns of clinical behaviour. Biological mechanisms leading to development of NHL are not clearly understood. Transforming growth factor-beta1 (TGF-beta1) influences B cell growth and developmen...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2005.12.010
更新日期:2006-02-07 00:00:00
abstract::Cytokine profile assessment is important to characterize immune responses to pathogens. To identify optimal time points for determination of cytokine profiles, we diluted whole blood 1:10, to enable daily cytokine measurements during one week. Cultures for 10 blood donors were set up in the presence of phytohemaggluti...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2006.01.005
更新日期:2006-02-07 00:00:00
abstract::Neuropilin-1 (NRP-1) is a co-receptor for vascular endothelial growth factor (VEGF). During neovascularization, vascular smooth muscle cells (VSMCs) and pericytes modulate the function of endothelial cells. Factors that mediate NRP-1 in human VSMCs (hVSMCs) remain to be elucidated. We studied various angiogenic cytoki...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2005.09.009
更新日期:2005-12-07 00:00:00
abstract::A large body of evidence supports the involvement of the immune system in the pathogenesis of multiple sclerosis (MS). Nevertheless, how the peripheral T-cells phenotypes are associated with factors such as the disability score, the effects of immunomodulatory treatments, or the activation period is poorly understood....
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2005.08.005
更新日期:2005-10-21 00:00:00
abstract::Intestinal epithelial cells can be induced to secrete the chemokine interleukin (IL)-8 during inflammation. The PAR-2 receptor is believed to play a proinflammatory role and is expressed in gut epithelial cells. The aim was to investigate PAR-2 signaling in Caco-2 intestinal epithelial cells, with respect to chemokine...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2005.06.004
更新日期:2005-09-07 00:00:00
abstract:INTRODUCTION:Although, hypothermia is a frequent event after trauma, it is unclear whether its beneficial or detrimental effects are more important. This study aims to quantify the effects of hypothermia and re-warming on the inflammatory response after fracture/hemorrhage and subsequent fracture stabilization with res...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2005.06.008
更新日期:2005-09-07 00:00:00
abstract::Functional diversity of the memory T-cell-derived cytokine IL-17 was explored at the receptor level. IL-17 inhibited TNF-induced chemokine Rantes expression in human synovial fibroblasts and mouse lung fibroblasts. This inhibitory activity of IL-17 (IC50=0.2 ng/ml) was 6-fold more potent than its stimulatory activity ...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2005.02.012
更新日期:2005-08-07 00:00:00
abstract::In order to understand the cellular disease mechanisms of osteoarthritic cartilage degeneration it is of primary importance to understand both the anabolic and the catabolic processes going on in parallel in the diseased tissue. In this study, we have applied cDNA-array technology (Clontech) to study gene expression p...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2005.04.009
更新日期:2005-08-07 00:00:00
abstract::A number of chemokines induce angiogenesis and endothelial cells express several chemokine receptors. To date, only a limited number of CC chemokines for CCR1 have been reported to induce angiogenic responses. We investigated the ability of CCL23 (also known as MPIF-1, MIP-3, or CKbeta8) to promote angiogenesis, which...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2005.01.018
更新日期:2005-06-07 00:00:00